SPHeRE Blog

Participants’ Perspectives and Preferences on Clinical Trial Result Dissemination: The TRUST Thyroid Trial Experience.

The results of clinical trials are not traditionally disseminated to clinical trial participants. While there is a growing awareness that participants should receive study results, little is known about the most appropriate methods of doing so. The Thyroid Hormone Replacement for Subclinical Hypothyroidism Trial (TRUST) was a multi-centre, double-blind, randomised, […]

Patients, Placebos, and Clinical Research: Making much ado about nothing

Researchers are required to furnish patients with information to enable them to make informed decisions. In medical research participants need to know: “What are the risks of participating? What are the risks of not participating? What are the possible benefits?” Providing this information is an ethical imperative. Studies show that […]

Lifestyle Approaches to Cholesterol Management

Cardiovascular disease (CVD) remains the leading cause of premature death and disability worldwide [1]. In Ireland, approximately 10,000 people die each year from CVD – including coronary heart disease (CHD), stroke and other circulatory diseases. While it is not possible to change the non-modifiable risk factors for CVD (such as age, ethnic background and […]

Prevalence of potentially inappropriate prescribing in a subpopulation of older European clinical trial participants: a cross-sectional study

Older people often have multiple comorbidities and as a consequence are frequently prescribed multiple drugs. This increases their risk of adverse drug events (ADEs), extended hospital stays and mortality 1. Potentially inappropriate prescribing (PIP) describes any drug that has the potential to cause an adverse event which can outweigh its […]

Cognitive impairment and medication adherence in stroke

Up to a third of all strokes are recurrent events, which tend to be more severe and lead to increased levels of disability. Medications to control cardiovascular risk factors, such as hypertension, dyslipidaemia and atrial fibrillation, are essential for secondary prevention. However, medication adherence is often poor, with up to […]

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SPHeRE PhD Applications Now Open for 2018/19

The SPHeRE Programme has opened the application process for applications to the 2018/19 PhD Programme. Applications are now open for the SPHeRE PhD Programme; the HRB will fund 3 Scholars in 2018/19, one to be enrolled in each of RCSI, Trinity College and UCC. Self-funded or alternatively-funded Scholars may apply […]

Patient reported health status and all-cause mortality in patients with coronary heart disease

Patients with coronary heart disease (CHD) typically have reduced health-related quality of life (HRQoL) compared to those without the disease. Self-rated health (SRH) can provide valuable information about individuals’ current health beyond what might be measured by clinical investigations or biomarkers. While far from perfect, and certainly not a replacement […]

The Cerebrovascular Nature of Schizophrenia

Schizophrenia is a brain disorder that affects approximately 1 % of the population and approximately 1.5 million people are newly diagnosed each year globally.  It is generally characterized by delusions (fixed and false beliefs), hallucinations (visual and auditory), and disorganized thinking and speech and begins in early adulthood and continues […]

Texting patients: what should GPs consider?

Substantial numbers of GPs currently text message their patients, and the number of text messages sent is increasing. The main objectives of this study were to assess the extent, growth, and perceived risks and benefits of text messaging by GPs to communicate with patients, and assess patients’ attitudes towards receiving […]

Dementia, Disclosing the Diagnosis

While numerous works have discussed formulation of a diagnosis of dementia there is little work to date on the practicalities involved in disclosing this diagnosis to a patient. We therefore outlined some of the key aspects of dementia diagnosis disclosure in a recent commentary published in the Quarterly Journal of […]